ABSTRACT
Polo-like kinase 1 (PLK1) is a critical molecule in the proliferation of several human cancers. Overexpression of PLK1 has been correlated with cancer cell proliferation and lower overall survival rates. Although PLK1 has been studied in various tumors, information regarding its expression in oral cancer and precancer is limited. Aims: This study is aimed at evaluating the expression of PLK1 in a potentially malignant and malignant disorder of the oral cavity, namely, oral submucous fibrosis (OSMF) and oral squamous cell carcinoma (OSCC), respectively, using the immunohistochemistry technique. It also intended to evaluate the association of the various histological grades of OSCC with the intensity of PLK1 expression. Subjects and Methods: Thirty OSMF, thirty OSCC tissues, and thirty control tissues were obtained, and the expression of PLK1 was detected by immunohistochemistry using rabbit antihuman PLK1 polyclonal antibodies (Abcam Ab47867). The association between staining intensity and histological grade of OSCC was evaluated. Statistical Analysis Used: Using SPSS 20 version, a test for proportions, nonparametric Chi-square/correlation analysis was used to compare differences in proportions of categorical variables of interest between groups. Results: PLK1 was positively expressed in 27 (90%) OSCC tissues. OSMF showed no detectable staining in 27 (90%) tissues and positive staining in 3 (10%) tissues. PLK1 showed no staining (0%) in normal tissues. Statistically significant associations were not found between staining intensity and histological grade of OSCC. Conclusions: PLK1 could be a promising progression marker for OSCC. Therapeutically, targeting PLK1 may be a new approach to fight oral cancer.
ABSTRACT
Fusion imaging is the amalgamation of various advanced imaging modalities used in oral and maxillofacial imaging today, which takes a lion share in improvising diagnostic and formulation of effective treatment outcomes. In today’s scenario, this has been widely accepted in various disciplines of dentistry in a broadened horizon for capturing the head and neck pathologies. This review paper therefore aims to highlight various aspects of fusion imaging with its bird’s view in various dental specialties
ABSTRACT
Plummer–Vinson syndrome (PVS) is a condition that can occur in people with long-term iron-deficiency anemia. It is a triad of dysphagia, iron deficiency anemia, and upper esophageal web(s). The post-cricoid web is associated with high-risk of development of squamous cell carcinoma of the esophageal region. Predominantly affected are middle-aged women in developing countries. Oral manifestations play an important part of the diagnosis of PVS. Timely diagnosis and treatment of this syndrome is important. An interesting case of PVS with typical clinical, oral and radiological findings previous to and post management of the syndrome are discussed in this report. It also includes a review of literature.